81-13-0 Usage
Description
Dexpanthenol belongs to a derivative of pantothenic acid (vitamin B5). It can penetrate the skin and mucous membrane to be quickly oxidized to pantothenic acid. The later one is extremely hygroscopic and binds water effectively. Therefore, Dexpanthenol can be used as a moisturizer. It is added to pharmaceutical and cosmetic products to relieve itching and improve wound healing. In ointments, it can be used for the treatment of sunburns, mild burns, minor skin injuries and disorders. It is also immediately applied after major abdominal surgery to minimize the possibility of paralytic ileus. In addition, it can also be supplemented into the commercial shampoos and hair conditioners to lubricate the hair shaft and give the hair a shiny appearance. The exact mechanism of action of Dexpanthenol is still unclear, perhaps through its enhancing effect on acetylcholine.
References
https://pubchem.ncbi.nlm.nih.gov/compound/Dexpanthenol#section=Top
https://www.drugs.com/pro/dexpanthenol.html
https://de.wikipedia.org/wiki/Dexpanthenol
Originator
Bepanthene,Roche,France,1951
Uses
Different sources of media describe the Uses of 81-13-0 differently. You can refer to the following data:
1. Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.
2. D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.
3. immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic
Manufacturing Process
130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid
lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by
weight of 3-hydroxypropylamine are added, in one portion, to the solution and
the mixture is well stirred. While the reaction sets in, the temperature of the
mixture gradually rises by itself to about 50°C and then drops again after
about two hours. To cause completion of the reaction, the mixture is allowed
to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from
methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It
boils under a pressure of 0.02 mm between 118° and 120°C.
Brand name
D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).
Therapeutic Function
Gastrointestinal drug
General Description
Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flammability and Explosibility
Nonflammable
Biochem/physiol Actions
D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.
Contact allergens
Pan(to)thenol is the alcohol corresponding to pantothenic
acid, of the vitamin B5 group. It is used as a food additive,
and in skin and hair products as a conditioning agent.
Contact dermatitis and urticaria have been reported.
Safety Profile
Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.
Veterinary Drugs and Treatments
Dexpanthenol has been suggested for use in intestinal atony or distension,
postoperative
retention of flatus and feces, prophylaxis and
treatment of paralytic ileus after abdominal surgery or traumatic
injuries, equine colic (not due to mechanical obstruction) and any
other condition
when there is an impairment of smooth muscle
function. Controlled studies are lacking with regard
to proving the
efficacy of the drug for any of these indications.
Purification Methods
Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]
Check Digit Verification of cas no
The CAS Registry Mumber 81-13-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 1 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 81-13:
(4*8)+(3*1)+(2*1)+(1*3)=40
40 % 10 = 0
So 81-13-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m1/s1
81-13-0Relevant articles and documents
Determination of panthenol enantiomers in cosmetic preparations using an achiral-chiral–coupled column HPLC system
Hroboňová, Katarína,Lomenova, Anna
, p. 191 - 199 (2019/12/15)
A new high-performance liquid chromatography (HPLC) method for separation and determination of panthenol enantiomers in hair care products was developed. Two types of detectors, low-wavelength ultraviolet (UV) and polarimetric, were used. Optimized conditions consisted of coupled achiral, amino type, and chiral, amylose tris(3,5-dimethylphenylcarbamate), stationary phases, mixture of n-hexane/ethanol (60:40, v/v) as mobile phase under isocratic conditions and flow rate 0.8 cm3 min?1. The effect of column temperature on retention and resolution of enantiomers was studied. The analysis runtime was 10 minutes, and the average retention times for d- and l-panthenol were 7.10 ±0.1 minutes and 8.21 ±0.2 minutes, respectively. The resolution of enantiomers on coupled achiral-chiral columns was Rs = 2.7. The solid-phase extraction method was employed for extraction and purification of analytes. The validated method was selective, accurate, and linear (R2 >.998) over the concentration range of 0.001 to 1.0 mg cm?3 for both enantiomeric forms. The limits of detection (LOD) and quantitation (LOQ) of each enantiomer were 0.3 and 1.0 μg cm?3, respectively. The results demonstrated the occurrence of d-panthenol in hair care products.
PROCESS FOR PREPARING AND PURIFYING 3-AMINOPROPANOL
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Page/Page column 10, (2012/06/18)
The present invention relates to a process for purifying a reaction output which comprises 3-aminopropanol and is obtained in the reaction of ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises distilling the reaction output comprising 3-aminopropanol in two or more stages, the ammonia content of the reaction output comprising 3-aminopropanol before introduction into the first distillation stage being 1% by weight or less and the temperature in the distillation stages being not more than 135° C. The invention further relates to a process for preparing 3-aminopropanol by reacting ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises performing the purification of the reaction output comprising 3-aminopropanol in accordance with the invention. The present invention further provides a process for preparing 3-aminopropanol derivatives, especially panthenol, acambrosate, mefenorex, domperidon, ifosamid or urapidil, from 3-amino-propanol prepared in accordance with the invention.
