One-pot synthesis of functionalized 3-(trifluoromethyl)phenols by [3+3] cyclization of 1,3-bis(silyl enol ethers) with α,β-unsaturated trifluoromethyl ketones

Article abstract of DOI:10.1002/ejoc.200700801

Functionalized 3-(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3-bis(silyl enol ethers) with readily available open-chained and cyclic α,β-unsaturated trifluoromethyl ketones. The reaction of 3,4-dihydro-5-(trifluoroacetyl)-2H-pyran with 1,3-bis(silyl enol ethers) resulted in a domino process to give new functionalized dihydropyrans. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.