Design and Synthesis of a Potent and Specific Renin Inhibitor with a Prolonged Duration of Action in Vivo

Article abstract of DOI:10.1021/jm00160a049

A structure-activity analysis of peptides containing backbone C^α-methyl and N^α-methyl modifications led to the discovery of potent renin inhibitors with high metabolic stability.In vitro, Boc-Pro-Phe-N^α-MeHis-Leuψ