Design and Synthesis of a Potent and Specific Renin Inhibitor with a Prolonged Duration of Action in Vivo

DOI: 10.1021/jm00160a049

Source and publish data:

Journal of Medicinal Chemistry p. 2088 - 2093 (1986)

Update date:2022-09-26

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Authors:

Thaisrivongs, Suvit

Pals, Donald T.

Harris, Douglas W.

Kati, Warren M.

Turner, Steve R.

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Article abstract of DOI:10.1021/jm00160a049

A structure-activity analysis of peptides containing backbone C^α-methyl and N^α-methyl modifications led to the discovery of potent renin inhibitors with high metabolic stability.In vitro, Boc-Pro-Phe-N^α-MeHis-Leuψ

Full text of DOI:10.1021/jm00160a049

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