Journal of the Chemical Society. Perkin transactions I p. 881 - 891 (1991)
Update date:2022-08-04
Topics:
Brown, Pamela
Calvert, Stephen H.
Chapman, Pauline C. A.
Cosham, Suzanne C.
Eglington, A. John
et al.
A series of (Z)-2-alkyloxyimino-2-(2-aminothiazol-4-yl)acetamidopenicillins has been prepared.New methodology has been developed to prepare tertiary alkyl oximes.High stability to β-lactamases and potent antibacterial activity have been achieved against Gram-positive and certain Gram-negative organisms.Activity against methicillin-resistant Staphylococcus aureus was an unexpected finding.The cyclopentyl analogue 4f, BRL 44154, has been selected for further study.
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