HIGHLY ANTI DIASTEREOSELECTIVE REDUCTION OF 2-ALKYL-3-OXO AMIDES BY POTASSIUM TRIETHYLBOROHYDRIDE

DOI: 10.1016/S0040-4039(00)98774-4

Source and publish data:

Tetrahedron Letters p. 4643 - 4646 (1985)

Update date:2022-07-30

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Authors:

Ito, Yoshio

Katsuki, Tsutomu

Yamaguchi, Masaru

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Article abstract of DOI:10.1016/S0040-4039(00)98774-4

Potassium triethylborohydride was found to reduce 2-alkyl-3-oxo amides to the corresponding 3-hydroxy amides with excellent anti-diastereoselectivity (>99:1), and in combination with asymmetric acylation, a useful route to optically active anti-2-alkyl-3-

Full text of DOI:10.1016/S0040-4039(00)98774-4

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