Adamantyl amino acid as γ-turn inducer for peptide

Article abstract of DOI:10.1016/S0040-4039(97)10101-0

The structures of six peptide mimics having different bulkiness and/or rigidity of the amino acids were investigated spectroscopically. Comparison of H NMR, IR spectra and H-D exchangerate of the amide protons reveals that 2-amino-2-carboxyadamantane induces the high population of γ-turn conformation in the room temperature region and may be utilized as a promising γ-turn inducer for synthetic peptides.