Chemical and Pharmaceutical Bulletin p. 688 - 693 (1993)
Update date:2022-08-02
Topics:
Takeuchi
Sakamoto
Yoshida
Abe
Isomura
A series of aminomethylenebisphosphonate derivatives was synthesized and evaluated for their antiresorptive activities using a parathyroid hormone (PTH)-induced hypercalcemia model in rats (PIH model). Among these compounds, (cycloheptylamino)methylenebis(phosphonic acid) (3j) was finally selected for further investigation, proving 10-fold as potent as pamidronate in the PIH model and an immobilization bone atrophy model in rats (DA model). The structure-activity relationships of this series of bisphosphonates are discussed.
View MoreShangHai BMG Chemical Co., Ltd
Contact:+86-13524845543
Address:Room 602, no 291 sikai road shanghai
Contact:0833-5590788/5590338/5590055
Address:Victory in the town of Red Star Village,Mount Emei City,industrial concentration area storage processing logistics parkpark
website:http://www.cheminn.com/
Contact:86-531-67875205
Address:No.9-2,South of Shanda Road, Jinan ,China
Contact:86-21-57725962
Address:shanghai
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Doi:10.1002/jhet.5570220541
(1985)Doi:10.1002/poc.3230
(2013)Doi:10.1055/s-2008-1072588
(2008)Doi:10.1021/acsmedchemlett.6b00465
(2017)Doi:10.1002/jccs.200700152
(2007)Doi:10.1007/BF00776329
(1986)