(4-Piperidinyl)-piperazine: A new platform for acetyl-CoA carboxylase inhibitors

DOI: 10.1016/j.bmcl.2009.10.012

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 6645 - 6648 (2009)

Update date:2022-07-29

Topics:

Authors:

Chonan, Tomomichi

Oi, Takahiro

Yamamoto, Daisuke

Yashiro, Miyoko

Wakasugi, Daisuke

Tanaka, Hiroaki

Ohoka-Sugita, Ayumi

Io, Fusayo

Koretsune, Hiroko

Hiratate, Akira

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Article abstract of DOI:10.1016/j.bmcl.2009.10.012

Acetyl-CoA carboxylases (ACCs), the rate limiting enzymes in de novo lipid synthesis, play important roles in modulating energy metabolism. The inhibition of ACC has demonstrated promising therapeutic potential for treating obesity and type 2 diabetes mel

Full text of DOI:10.1016/j.bmcl.2009.10.012

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