N-phenyl>methanesulfonamide. A Potent Agonist Which Releases Intracellular Calcium by Activation of α1-Adrenoceptors

DOI: 10.1021/jm00380a017

Source and publish data:

Journal of Medicinal Chemistry p. 245 - 248 (1985)

Update date:2022-08-03

Topics:

Authors:

DeMarinis, Robert M.

Lavanchy, Patricia

Hieble, J, Paul

Jim, Kam F.

Matthews, William D.

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Article abstract of DOI:10.1021/jm00380a017

N-<2-hydroxy-5-<2-(methylamino)ethyl>phenyl>methanesulfonamide (SKandF 102652) has been prepared and characterized pharmacologically.It is a potent agonist with an EC50 of 25 nM at α₁-adrenoceptors as determined in the isolated perfused rabbit

Full text of DOI:10.1021/jm00380a017

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