A CONVENIENT AND GENERAL APPROACH TO THE SYNTHESIS OF PROPERLY PROTECTED d-NUCLEOSIDE-3'-HYDROGENPHOSPHONATES VIA PHOSPHITE INTERMEDIATES

DOI: 10.1016/S0040-4039(00)84611-0

Source and publish data:

Tetrahedron Letters p. 2661 - 2664 (1986)

Update date:2022-08-04

Topics:

Authors:

Marugg, J. E.

Tromp, M.

Kuyl-Yeheskiely, E.

Marel, G. A. van der

Boom, J. H. van

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Article abstract of DOI:10.1016/S0040-4039(00)84611-0

Evidence will be presented to show that the monofunctional phosphitylating reagents bis(N,N-di-ethylamino)chlorophosphine and salicylchlorophosphine are very effective for the preparation of 5'-O,N-protected d-nucleoside-3'-hydrogenphosphonates.

Full text of DOI:10.1016/S0040-4039(00)84611-0

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