Assembly of homoallylamine derivatives through iron-catalyzed three-component sulfonamidoallylation reaction

Article abstract of DOI:10.1002/aoc.3334

An efficient FeCl₃-catalyzed three-component reaction between aldehydes, sulfonamides and allylsilanes has been achieved, which provides a convenient, atom-economic and green way to construct homoallylamine derivatives. In addition, this reaction exhibits excellent syn stereoselectivity with γ-substituted allylsilanes. A practical three-component cascade process to homoallylamine derivatives is reported, which uses cheap and environmentally benign FeCl₃ as catalyst and shows excellent syn stereoselectivity with γ-substituted allylsilanes.