Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

Article abstract of DOI:10.1021/jm00384a021

Chromophore modification of the anthracenediones related to mitoxantrone in an attempt to provide agents with diminished or no cardiotoxicity has resulted in a novel class of DNA binders, the anthrapyrazoles. Their synthesis was carried out by a two-stage