Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias

DOI: 10.1021/jm00384a021

Source and publish data:

Journal of Medicinal Chemistry p. 121 - 131 (1987)

Update date:2022-08-05

Topics:

Authors:

Showalter

Johnson Johnson

Hoftiezer

Turner Turner

Werbel Werbel

Leopold Leopold

Shillis Shillis

Jackson Jackson

Elslager

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Article abstract of DOI:10.1021/jm00384a021

Chromophore modification of the anthracenediones related to mitoxantrone in an attempt to provide agents with diminished or no cardiotoxicity has resulted in a novel class of DNA binders, the anthrapyrazoles. Their synthesis was carried out by a two-stage

Full text of DOI:10.1021/jm00384a021

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