A synthetic approach to the fusicoccane A-B ring fragment based on a Pauson-Khand cycloaddition/Norrish type 1 fragmentation

DOI: 10.1021/jo800933f

Source and publish data:

Journal of Organic Chemistry p. 6711 - 6715 (2008)

Update date:2022-07-30

Topics:

Authors:

Dake, Gregory R.

Fenster, Erik E.

Patrick, Brian O.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo800933f

(Chemical Equation Presented) A synthetic approach to the A-B ring system within the fusicoccane family of diterpenes is presented. Key steps in this approach are a diastereoselective Pauson-Khand reaction, a Norrish 1 photofragmentation, a Charette cyclopropanation, and a ring-closing metathesis process.

Full text of DOI:10.1021/jo800933f

Products guided by the article

Product name:(1R,2S,3R)-2-(2-((1R,2R)-2-(iodomethyl)cyclopropyl)ethyl)-3-isopropyl-1-((2S)-2,3-O-isopropylidene-2,3-dihydroxypropyl)-1-methylcyclopentane

Cas No:1048342-06-8

R&D Labs maybe for 1048342-06-8

Hunan Haili Chemical Industry Co.,Ltd.

Contact:+86-731-85521860

Address:No.251, 2nd Section, Furong Road, Changsha,Hunan,China
Zhushan County Tianxin Pharmaceutical & Chemical Co., Ltd.

Contact:0086-719-4224892

Address:Tutang Road, Chengguan Town, Zhushan County, Hubei Province
Ji'an Kexin Trade Co., Ltd.(expird)

Contact:86-0796-8187704 18507063190

Address:ji'an jiangxi
Lishui Nanming Chemical Co., Ltd(expird)

Contact:+86-0578-2134101，2697830

Address:No.19 Tongji Road Shuige Industrial zone
Tianjin Boron PharmaTech Co.,Ltd.(expird)

Contact:86-022-59845187

Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China

Relevant to this article

Synthesis of indolines via a SmI₂ promoted domino nitro reduction-intramolecular aza-Michael reaction

Doi:10.1002/jhet.1982
(2015)
A practical and efficient route for the highly enantioselective synthesis of mexiletine analogues and novel β-thiophenoxy and pyridyl ethers

Doi:10.1021/jo801181d
(2008)
Detection of Sulfatase Enzyme Activity with a CatalyCEST MRI Contrast Agent

Doi:10.1002/chem.201600685
(2016)
Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis

Doi:10.1021/jo801159k
(2008)
Aromatization of enamines promoted by a catalytic amount of Pd/C. Synthesis of aromatic amines

Doi:10.1021/ol026184z
(2002)
O⁶-(Alkyl/aralkyl)guanosine and 2'-deoxyguanosine derivatives: Synthesis and ability to enhance chloroethylnitrosourea antitumor action

Doi:10.1021/jm960881d
(1997)

Article Doi