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Synthesis of 3'-O-(ω-Aminoalkoxymethyl)thymidine 5'-Triphosphates, Terminators of DNA Synthesis that Enable 3'-Labelling

DOI: 10.1039/P19940000211

Source and publish data:

Journal of the Chemical Society. Perkin transactions I p. 211 - 218 (1994)

Update date:2022-08-04

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Authors:

Hovinen, JariHovinen, Jari

Azhayeva, ElenaAzhayeva, Elena

Azhayev, AlexAzhayev, Alex

Guzaev, AndreiGuzaev, Andrei

Loennberg, HarriLoennberg, Harri

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Article abstract of DOI:10.1039/P19940000211

Treatment of 5'-O-benzoylthymidine 1 with a mixture of acetic anhydride, acetic acid and dimethyl sulfoxide yielded 5'-O-benzoyl-3'-O-methylthiomethylthymidine 2, which was converted via the 3'-O-bromomethyl derivative into 3'-O-(ω-aminoalkoxymethyl)thymi

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Product name:Benzoic acid (2R,3S,5R)-3-(10-bromo-decyloxymethoxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

Cas No:1055033-09-4

1055033-09-4

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