A CONVENIENT SYNTHESIS OF 4(5)-MONO-, 4,5-DI-, AND 2,4,5-TRI-SUBSTITUTED IMIDAZOLES

DOI: 10.1016/S0040-4039(00)84334-8

Source and publish data:

Tetrahedron Letters p. 1635 - 1638 (1986)

Update date:2022-08-04

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Authors:

Iddon, Brian

Khan, Nazir

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Article abstract of DOI:10.1016/S0040-4039(00)84334-8

A procedure is described for the stepwise introduction of substituents (hydrogen included) into the imidazole ring by FGI of the bromine atoms in 1-protected 2,4,5-tribromo-imidazoles in the order 2-5-4 using halogen-metal exchange techniques.

Full text of DOI:10.1016/S0040-4039(00)84334-8

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