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62613-82-5

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62613-82-5 Usage

Indications and Usage

Oxiracetam is a more potent derivative of the nootropic drug piracetam. They were developed in 1974 by the Italian company ICF and went on sale in 1987. Oxiracetam is a Piracetam derivative and excites the central nervous system, promotes brain metabolism, significantly increases and promotes memory retention, and effectively treats senile memory and mental decline. It is used to treat brain dysfunction psychiatric syndrome and mental disorders. It can improve the memory and learning abilities of patients with senile dementia or memory disorders. It is suitable for treating neural dysfunction, memory disorder and intelligence disorders caused by brain damage. It can also be used as a recovery treatment for neurosis, brain trauma, encephalitis, and other brain diseases. Oxiracetam’s greatest advantage is that it is very soluble in water, making it suitable for injection. Research shows that Oxiracetam has higher pharmacological activity and significant curative effects compared to Piracetam.

Mechanisms of Action

Oxiracetam’s mechanisms of action are similar to those of Piracetam. It promotes the binding of phosphorylcholine and phosphoethanolamine, increases the ratio of ATP/ADP in the brain, and increases the binding of protein with nucleic acids in the brain, thus improving the memory and learning ability of patients with senile dementia and memory disorder.

Pharmacokinetics

After intake, most of the drug will not accumulate in the body and will be excreted through urine in its original form. It is well-absorbed and well-tolerated.

Clinical Research

Animal trials showed that in all types of behavioral experiments, Oxiracetam can improve memory retention and learning ability, reduce brain shocks’ damage on memory, and prevent the learning abilities of rats suffering from spontaneous hypertensive cerebrovascular injury from decreasing. It can also increase acetylcholine circulation in rats’ skin and hippocampus, thus increasing affinity for choline uptake.

Description

Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.

Originator

ISF (Italy)

Uses

Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.

Brand name

Neuromet

Biochem/physiol Actions

Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.

Purification Methods

This nootropic (Alzheimer) drug is purified by recrystallisation from MeOH or aqueous Me2CO and dried in vacuo. [NMR, IR: Pifferi & Pinza Farmaco Ed Sci 32 602 1977, Banfi et al. Farmaco Ed Sci 39 16 1984, Gouilaev & Senning Brain Research Rev 19 180 1994.]

Check Digit Verification of cas no

The CAS Registry Mumber 62613-82-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,6,1 and 3 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 62613-82:
(7*6)+(6*2)+(5*6)+(4*1)+(3*3)+(2*8)+(1*2)=115
115 % 10 = 5
So 62613-82-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H10N2O3/c7-5(10)3-8-2-4(9)1-6(8)11/h4,9H,1-3H2,(H2,7,10)

62613-82-5 Well-known Company Product Price

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  • TCI America

  • (O0398)  Oxiracetam  >96.0%(GC)(N)

  • 62613-82-5

  • 1g

  • 590.00CNY

  • Detail
  • TCI America

  • (O0398)  Oxiracetam  >96.0%(GC)(N)

  • 62613-82-5

  • 5g

  • 1,990.00CNY

  • Detail

62613-82-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Hydroxy-2-Oxopyrrolidine-N-Acetamide

1.2 Other means of identification

Product number -
Other names 4-Hydroxy-2-oxopyrrolidine-N-acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:62613-82-5 SDS

62613-82-5Relevant articles and documents

Preparation method 2 - (4 -hydroxy -2 - oxo -1 - pyrrolidinyl) acetamide (by machine translation)

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Paragraph 0030; 0034; 0035; 0037; 0041; 0042, (2019/07/29)

The invention relates to the field, organic synthesis and medicine technology. In particular, the invention provides a method for preparing 2 - (4 -hydroxy -2 - oxo -1 - pyrrolidinyl) acetamide, which uses methyl 4 - chloroacetoacetate as a starting material, condenses, crystallizes and crystallizes after carbonyl reduction to obtain a target product, and the total yield is approximately unitz 90% is left and right. The method optimizes the reaction steps by improving the synthesis route, namely the 2 - (4 - hydroxyl -2 - oxo -1 - pyrrolidinyl) acetamide, and shortens the production cycle, and shortens the production cycle. The production cost, as well as the emission. The method is cheap and easy to obtain, simple and convenient to operate, low in impurities, high in yield, and particularly suitable for industrial production. (by machine translation)

A synthesis process of oxiracetam

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Paragraph 0046-0049, (2019/01/16)

The invention discloses a synthetic method for an anti-senile dementia drug of oxiracetam (I), and mainly provides a novel synthetic route. The method comprises the following steps of reacting a compound (when R is -Me and NO2) shown as a formula (V) with glycinamide hydrochloride of a compound shown as a formula (VI) under an alkaline condition to obtain a compound (wherein R is -Me and NO2) shown as a formula (IV); reacting the compound (wherein R is -Me and NO2) shown as the formula (IV) with ethyl 4-chloro-3-hydroxybutyrate of a compound shown as a formula (III) to obtain a compound (wherein R is -Me and NO2) shown as a formula (II); then removing protection groups under an acidic condition and intramolecularly cyclizing to obtain a compound shown as the formula (I) of 4-hydroxy-2-oxo-1-pyrrolidine acetamide, the compound (I) being oxiracetam. According to the synthetic route, raw materials and reagents have low toxicity, low cost and easy availability. The synthetic route is simple to operate, has relatively high yield and is suitable for industrial production.

Oxiracetam synthesis technology

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Paragraph 0034, (2017/02/28)

The invention belongs to the field of pharmaceutical chemicals and particularly relates to an oxiracetam synthesis technology, ethyl acetoacetate and glycine are taken as the raw materials, the ethyl acetoacetate is changed into 4-halogeneated ethyl acetoacetate by halogenation reaction, the 4-halogeneated ethyl acetoacetate and glycine ester formed by the glycine are cyclized to form 2,4-dioxo-1-pyrrolidine acetate, and 4-hydroxy-2-oxo-1-pyrrolidineacetamide is obtained after hydrolysis and aminolysis. According to the oxiracetam synthesis technology, the related raw materials are easy to obtain, and the synthesis technology is simple and has good industrial values.

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