Journal of Medicinal Chemistry p. 586 - 588 (1987)
Update date:2022-07-30
Topics:
Lee, Kuo-Hsiung
Rice, Gregory K.
Hall, Iris H.
Amarnath, Venkataraman
α-Methylene-γ-lactones covalently linked to adenine (3), hypoxantine (4), and guanine (5) were synthesized by using the convenient Reformatsky-type reaction between ethyl α-(bromomethyl)acrylate and the proper purine ketones.In vitro cytotoxicity data demonstrated that these compounds were active against L-1210 tissue culture cells with 3 being most potent (ED50 = 0.3 μg/mL).
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