Journal of Medicinal Chemistry p. 586 - 588 (1987)
Update date:2022-07-30
Topics:
Lee, Kuo-Hsiung
Rice, Gregory K.
Hall, Iris H.
Amarnath, Venkataraman
α-Methylene-γ-lactones covalently linked to adenine (3), hypoxantine (4), and guanine (5) were synthesized by using the convenient Reformatsky-type reaction between ethyl α-(bromomethyl)acrylate and the proper purine ketones.In vitro cytotoxicity data demonstrated that these compounds were active against L-1210 tissue culture cells with 3 being most potent (ED50 = 0.3 μg/mL).
View MoreZhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Hubei Xinghuo Chemical Co., Ltd.,
Contact:13925817279 13907299441
Address:Xinghuo Fine Chemistry Industrial Park, Xiaochang County, Hubei Province, China
Xiamen Kaijia Imp & Exp Co., Ltd.
Contact:86-592-5101177
Address:Room406 Luhui Building No. 65 Haitian Road Huli Xiamen,China.
Taizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
Doi:10.1071/ch99151
(2000)Doi:10.1016/S0022-328X(00)93214-5
(1976)Doi:10.1016/j.bmc.2011.09.021
(2011)Doi:10.1002/hlca.19880710618
(1988)Doi:10.1016/j.tet.2010.06.083
(2010)Doi:10.1016/S0022-328X(00)00627-6
(2000)
