220127-57-1

Basic information

• Product Name: Imatinib mesylate
• Synonyms: 4-[(4-methyl-1-piperazinyl)methyl]-n-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-benzamide monomethanesulfonate;STI-571;IMATINIB BASE(IMA-3);ImatinibMesylate/Gleevec;Imatinib Methanesulfonate, STI-571, CGP-57148B, Glivec,;IMATINIB MESYLATE (IMATINIB METHANESULFONATE);alpha-IMATINIB MESYLATE;Imatinib mesylate(TINIBS )
• CAS NO: 220127-57-1
• Molecular Formula: C30H35N7O4S
• Molecular Weight: 589.71
• EINECS: 1308068-626-2
• Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Aromatics;Heterocycles;API;Glivec, CGP-57148B, STI-571;Antineoplastic;Anti-cancer&immunity;Inhibitors;Anticancer
• Mol File: 220127-57-1.mol

Chemical Properties

• Melting Point: 214-224°C
• Boiling Point: 754.9 °C at 760 mmHg
• Flash Point: 410.3 °C
• Appearance: white to beige/
• Density: 0.858g/mLat 25°C(lit.)
• Storage Temp.: -20°C Freezer
• Solubility: H2O: soluble10mg/mL, clear
• CAS DataBase Reference: Imatinib mesylate(CAS DataBase Reference)
• NIST Chemistry Reference: Imatinib mesylate(220127-57-1)
• EPA Substance Registry System: Imatinib mesylate(220127-57-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• RTECS: CV5520550
• Hazardous Substances Data: 220127-57-1(Hazardous Substances Data)

Usage

a small-molecule inhibitor

Imatinib mesylate (also called Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the causal agent in chronic myelogenous leukemia.
As an inhibitor of PDGFR, imatinib mesylate appears to have utility in the treatment of a variety of dermatological diseases. Imatinib has been reported to be an effective treatment for FIP1L1-PDGFRalpha+ mast cell disease, hypereosinophilic syndrome, and dermatofibrosarcoma protuberans.

Chemical Properties

Off-White Solid

Uses

echinocandin antifungal, active against infections with Aspergillus and Candida, inhibits cell wall synthesis

Uses

A tyrosine kinase inhibitor. Highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL)

Uses

Imatinib Mesylate (STI571) is an orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively.

Uses

Imatinib Mesylate is orally bioavailability mesylate salt of Imatinib, which is a multi-target inhibitor of v-Abl, c-Kit and PDGFR with IC50 of 0.6 μM, 0.1 μM and 0.1 μM, respectively. Imatinib also known as Gleevec, Glivec, CGP-57148B, STI-571 & Imatinib

Definition

ChEBI: A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.

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