Tetrahedron p. 3689 - 3696 (1986)
Update date:2022-07-29
Topics:
Bergman, Jan
Brynolf, Anna
Vuorinen, Eino
Addition of Grignard or organolithium reagents to N-(α-haloacyl)-N-alkylsubstituted anthranilonitriles (e.g.N-(2-bromopropionyl)-N-methyl-2-cyanoaniline)induced anion formation followed by cyclization to 4-amino-2-quinolinones (e.g. 4-amino-1,3-dimethyl-2-quinolinone (10)).Substrates lacking α-hydrogen atoms, such as N-α-bromoisobutyryl)-2-cyanoaniline, also yielded 3,3-dimethylquinolinedione (9b) by cyclization.In these cases the initial step is a halogen-metal exchange reaction.
View MoreChongqing Shuangfeng Chemical Co.,Ltd
Contact:+86-23-49850156
Address:No.663,xuanhua Rd,yongchuan,chongqing,China
Nanjing Legend Pharmaceutical & Chemical Co., Ltd.
Contact:+86-25-83767696
Address:14-7 Zhongshan Lu Guluo District, Nanjing
Contact:86-10-62983737; +86-10-51287608
Address:4/F Building C, 2 Shangdi Xinxi Road
Contact:18669908765
Address:Zibo City, Shandong Province, P.R.China
Tengzhou Runlong Fragrance Co., Ltd.
website:http://www.tzrunlong.com/
Contact:0086-15665710862
Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
Doi:10.1021/jo01126a006
(1955)Doi:10.1021/ol016022n
(2001)Doi:10.1016/S0040-4020(01)98479-0
(1964)Doi:10.1016/j.tetlet.2008.07.126
(2008)Doi:10.1016/j.carres.2008.07.016
(2008)Doi:10.1016/j.bmcl.2008.07.101
(2008)
