Tetrahedron p. 3689 - 3696 (1986)
Update date:2022-07-29
Topics:
Bergman, Jan
Brynolf, Anna
Vuorinen, Eino
Addition of Grignard or organolithium reagents to N-(α-haloacyl)-N-alkylsubstituted anthranilonitriles (e.g.N-(2-bromopropionyl)-N-methyl-2-cyanoaniline)induced anion formation followed by cyclization to 4-amino-2-quinolinones (e.g. 4-amino-1,3-dimethyl-2-quinolinone (10)).Substrates lacking α-hydrogen atoms, such as N-α-bromoisobutyryl)-2-cyanoaniline, also yielded 3,3-dimethylquinolinedione (9b) by cyclization.In these cases the initial step is a halogen-metal exchange reaction.
View MoreCompro Shijiazhuang Fine Chemical Co., Ltd
Contact:0086-311-89689838
Address:Economic and Technological Development Zone of Shijiazhuang,Hebei
Chengdu ZY Biochemical Technology Co., LTD
Contact:0086-28-88680086
Address:170 Qingpu Road, Shouan Town, Pujiang County
Kunshan Yalong Trading Co,.Ltd
Contact:86-512-57621185
Address:805-807 Room Hongqiao Mansion ,1088 West Qianjin Road, Kunshan, Jiangsu，China
ZHUHAI HAIRUIDE BIOSCIENCE AND TECHNOLOGY CO.,LTD
website:http://www.zhhairuide.com
Contact:+8613326687259/+86-756-7789199
Address:No.10 Yonghui Road
website:https://www.synose.com/
Contact:86-579-82275537
Address:No.1958 Liyu Road , jinhua,zhejiang,China
Doi:10.1021/jo01126a006
(1955)Doi:10.1021/ol016022n
(2001)Doi:10.1016/S0040-4020(01)98479-0
(1964)Doi:10.1016/j.tetlet.2008.07.126
(2008)Doi:10.1016/j.carres.2008.07.016
(2008)Doi:10.1016/j.bmcl.2008.07.101
(2008)
