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107724-20-9

Basic Information
CAS No.: 107724-20-9
Name: Eplerenone
Molecular Structure:
Molecular Structure of 107724-20-9 (Eplerenone)
Formula: C24H30O6
Molecular Weight: 414.49
Synonyms: Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-,?- lactone,methyl ester,(7R,11R,17R)-;9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester;Cgp 30083;Epoxymexrenone;SC-66110;Inspra;Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)-;Eplerenone(& the intermediates);Inspra (TN);Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-γ,-lactone,methyl ester,(7a,11a,17a);Pregn-4-ene-7,21-dicarboxylic acid,9,11-epoxy-17-hydroxy-3-oxo-,?- lactone,methyl ester,(7R,11R,17R)-;
EINECS: 600-850-8
Density: 1.31 g/cm3
Melting Point: 241-243 °C
Boiling Point: 597.933 °C at 760 mmHg
Flash Point: 259.474 °C
Solubility:
Appearance: White solid
Hazard Symbols:
Risk Codes:
Safety:
Transport Information:
PSA: 82.20000
LogP: 3.12450
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Specification

1. Introduction of Eplerenone

Eplerenone, with its systematic name of Methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate, is one kind of white crystalline powder. Its Classification Code are including Aldosterone antagonist; Aldosterone antagonists; Antihypertensive; Hormone Antagonists; Hormones, Hormone Substitutes, and Hormone Antagonists.

2. Properties of Eplerenone

Eplerenone has the following datas: (1)Index of Refraction: 1.587; (2)Molar Refractivity: 106.122 cm3; (3)Molar Volume: 315.658 cm3; (4)Surface Tension: 53.062 dyne/cm; (5)Density: 1.313 g/cm3; (6)Flash Point: 259.474 °C; (7)Enthalpy of Vaporization: 89.051 kJ/mol; (8)Boiling Point: 597.933 °C at 760 mmHg; (9)Vapour Pressure: 0 mmHg at 25 °C; (10)Melting Point: 241-243 °C.

3. Use of Eplerenone

Eplerenone is an aldosterone antagonist used as an adjunct in the management of chronic heart failure. Eplerenone is used alone or in combination with other medications to treat high blood pressure.Common adverse drug reactions associated with the use of Eplerenone include: hyperkalaemia, hypotension, dizziness, altered renal function, and increased creatinine concentration.