Asymmetric synthesis of β-nitro ketones via Michael addition of lithiated α-amino nitriles to nitroalkenes

DOI: 10.1021/jo8017318

Source and publish data:

Journal of Organic Chemistry p. 9641 - 9646 (2008)

Update date:2022-07-30

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Authors:

Enders, Dieter

F?rster, Dominik

Raabe, Gerhard

Bats, Jan W.

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Article abstract of DOI:10.1021/jo8017318

(Chemical Equation Presented) α-Amino nitriles, easily prepared from aldehydes, KCN, and an enantiopure secondary amine auxiliary, are metalated and used as nucleophiles in asymmetric Michael additions to nitroalkenes to afford the Michael adducts in good

Full text of DOI:10.1021/jo8017318

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