Coupling Reaction of Grignard Reagents with α,ω-Dibromoalkanes in the Presence of Copper(I) Bromide-HMPA: Preparation of α,ω-Bis(vinylaryl)alkanes

Article abstract of DOI:10.1246/bcsj.59.2035

The coupling reaction of Grignard reagents with α,ω-dibromoalkanes took place smoothly in THF/HMPA (12:1) in the presence of a catalytic amount of copper(I) bromide and gave the products in 60-100 percent yields.Several α,ω-bis(vinylaryl)alkanes were prepared in reasonable yields by the application of this reaction.