Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[ω-[4-[(alkylsulfonyl)amino]phenyl]-ω-hydroxyalkyl]-1H-im dazolium salts and related compounds

Article abstract of DOI:10.1021/jm00395a021

Novel analogues of the class III antiarrhythmic agent 1-[2-hydroxy-2-[4-[(methylsulfonyl)amino]phenyl]ethyl]-3-methyl-1H-im dazolium chloride, 1 (CK-1649), were prepared and investigated for their class III electrophysiological activity on isolated canine