Tetrahedron p. 10945 - 10958 (1993)
Update date:2022-08-04
Topics:
Franzen, Robert
Kronberg, Leif
The syntheses of chlorinated 5-hydroxy-furanones with a mono-, di-, and trichloromethyl group at C-5 are described.The 5-chloromethyl hydroxyfuranones were obtained by chlorination of levulinic acid followed by triethylamine promoted elimination of hydrogen chloride.Hydrolyses of chlorinated 4-cyclopentene-1,3-diones yielded 5-dichloromethyl hydroxyfuranones.The trichloromethyl group was incorporated to maleic anhydride through thermal decomposition of sodium trichloroacetate.
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