ASYMMETRIC DIALKYLATION OF α-CYANOACETIC ACID

DOI: 10.1016/S0040-4039(00)84556-6

Source and publish data:

Tetrahedron Letters p. 2463 - 2464 (1986)

Update date:2022-07-29

Topics: Monitor the reaction Characterize the product Optimize Reaction Conditions Prepare the Reaction Mixture

Authors:

Hanamoto, Takeshi

Katsuki, Tsutomu

Yamaguchi, Masaru

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Article abstract of DOI:10.1016/S0040-4039(00)84556-6

Formation of the quarternary asymmetric center by double alkylation of cyanoacetamide enolate bearing trans-2,5-bis(methoxymethoxymethyl)pyrrolidine moiety as a chiral auxiliary, was carried out with high diastereoselectivity.

Full text of DOI:10.1016/S0040-4039(00)84556-6

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Product name:2-Benzyl-3-((2R,5R)-2,5-bis-methoxymethoxymethyl-pyrrolidin-1-yl)-3-oxo-propionitrile

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