Journal of Organic Chemistry p. 1477 - 1481 (1984)
Update date:2022-08-04
Topics:
Mir-Mohamad-Sadeghy, Bagher
Rickborn, Bruce
The reaction of O-ethylphthalidium tetrafluoroborate (1) with excess NaOCH3 in CH3OH gives ortho ester 4 as the major product.The mechanism of formation of this solvent-derived material is explored.A plausible intermediate, 1-ethoxyisobenzofuran (8), has been prepared and isolated in solution; 8 reacts readily with, e.g., CH3OD to give the mixed ortho ester 5 contaning ca. one deuterium/mole.This indicates that 8 reacts by rate-determining proton transfer, followed by collapse of the ion pair to give 5.On these and other grounds, 8 is ruled out as an intermediate in the reaction of 1 leading to 4.A mechanism for the latter process consistent with all observations is presented, involving rapid consumption of local alkoxide ion concentration followed by rapid exchange with solvent and eventual neutralization by diffusion of alkoxide from the bulk medium.
View MoreContact:86-575-86132822,86-575-86085355
Address:No.418 Dadao West Road,Qixing Street,Xinchang, Zhejiang Province, China.
YingYing Pharmaceutical Co.,Ltd
Contact:86-18854126208
Address:55#, yingxiongshan road
Tianjin Crest Pharmaceutical R&D Co., Ltd. (Tianjin Yao Technology Development Co., Ltd.)(expird)
Contact:+86-22-66211386
Address:Building B5-405, No, 80 4th Avenue, TEDA, Tianjin, China P.R. 300457
Shanghai Goyic Pharmaceutical&Chemical Co,. Ltd
Contact:+86-021-60275964
Address:No. 528 ruiqing road
ZHEJIANG CHEMICAL INDUSTRY INSTITUTE TECHNOLOGY CO.,LTD(expird)
Contact:86-575-82730298
Address:shangyu
Doi:10.1021/jo00391a007
(1987)Doi:10.1016/S0040-4039(03)01026-8
(2003)Doi:10.1016/S0008-6215(00)83500-4
(1975)Doi:10.1021/jacs.7b07104
(2017)Doi:10.1246/bcsj.39.253
(1966)Doi:10.1016/j.tetlet.2005.04.085
(2005)