Journal of Medicinal Chemistry p. 861 - 867 (1990)
Update date:2022-08-04
Topics:
Ponpipom
Hagmann
O'Grady
Jackson
Wood
Zweerink
6-(5-Cholesten-3β-yloxy)hexyl 1-thio-β-D-mannopyranoside (L-644,257) enhances natural host resistance in cyclophosphamide-treated mice against Pseudomonas aeruginosa in a dose-dependent manner. It is active sc, im, and ip but not orally. L-644,257 is substantially more protective against P. aeruginosa than its α anomer. The β-L-fucose glycolipid is more effective when given im and ip than sc. The lactose and β-D-glucose glycolipids were only marginally effective to nonprotective. The 17β-steroidal side chain of L-644,257 can be modified without substantial loss of protective activity.
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