Tetrahedron p. 5149 - 5156 (1986)
Update date:2022-07-30
Topics:
Zhou, X-X.
Chattopadhyaya, J.
A study of four different O-4 and N-3 protected uridine derivatives, 4 to 7, for their stabilities under different conditions versus their abilities to undergo nucleophilic substitution reaction at C-4 by an appropriate oxygen or a nitrogen nucleophile has established a general strategy for the site-specific modification of a particular pyrimidine residue in a model fully protected diuridylic acid to give either UpC, CpC or UpU, depending upon the deprotection condition.
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