SITE-SPECIFIC MODIFICATION OF THE PYRIMIDINE RESIDUE DURING THE DEPROTECTION OF THE FULLY-PROTECTED DIURIDYLIC ACID.

Article abstract of DOI:10.1016/S0040-4020(01)88067-4

A study of four different O-4 and N-3 protected uridine derivatives, 4 to 7, for their stabilities under different conditions versus their abilities to undergo nucleophilic substitution reaction at C-4 by an appropriate oxygen or a nitrogen nucleophile has established a general strategy for the site-specific modification of a particular pyrimidine residue in a model fully protected diuridylic acid to give either UpC, CpC or UpU, depending upon the deprotection condition.