PREPARATION OF BOTH ENANTIOMERS OF A CHIRAL LACTONE THROUGH COMBINED MICROBIOLOGICAL REDUCTION AND OXIDATION

Article abstract of DOI:10.1016/S0040-4039(00)95923-9

The Baeyer-Williger-like oxidation of (R,S)-2,2,5,5-tetramethyl-4-hydroxy-cyclohexanone by several fungal strains was highly enantioselective, affording a rearranged (S)-hydroxy-γ-lactone.The recovery of the nearly optically pure (R)-hydroxyketone allowed