SYNTHESIS OF FLUORINATED α-AMINO KETONES. PART II: α-ACYLAMINOALKYL α',α'-DIFLUOROALKYL KETONES

DOI: 10.1016/S0040-4039(00)84972-2

Source and publish data:

Tetrahedron Letters p. 4437 - 4440 (1986)

Update date:2022-08-02

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Authors:

Kolb, Michael

Neises, Bernhard

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Article abstract of DOI:10.1016/S0040-4039(00)84972-2

The synthesis of α-acylaminoalkyl 1.1-difluoro-3-butenyl ketones 2 is described.Reaction of substituted 5(4H)-oxazolones 4, obtained from α-amino acids, with 2.2-difluoro-4-pentenoic acid anhydride 3 (for R²=C6H5) or with 2.2-difluoro-4-penteno

Full text of DOI:10.1016/S0040-4039(00)84972-2

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