SYNTHESIS OF 5-SUBSTITUTED 4-O-METHYL TETRAMATES

Article abstract of DOI:10.1016/S0040-4039(00)85192-8

4-Methoxy-Δ³-pyrrolin-2-ones (4-O-methyl tetramates) are alkylated at C-5 via a lithio-derivative; an N-substituent may be introduced either during or after heterocycle formation.