Bioorganic and Medicinal Chemistry Letters p. 4504 - 4507 (2016)
Update date:2022-08-04
Topics:
Dai, Hong
Ge, Shushan
Li, Gang
Chen, Jia
Shi, Yujun
Ye, Linyu
Ling, Yong
A series of new pyrazole oxime compounds bearing a 1,2,3-thiadiazole ring were designed, synthesized, and evaluated for their insecticidal, acaricidal and antitumor activities. Bioassays demonstrated that some title compounds displayed satisfactory insecticidal and acaricidal properties. Especially, compounds 8d and 8h exhibited 90% insecticidal activities against Aphis craccivora at the concentration of 100?μg/mL. Interestingly, some of the target compounds possessed significant antitumor activities against four human cancer cell lines in vitro. Among them, compounds 8e (IC50?=?7.19?μM), 8l (IC50?=?6.56?μM), 8m (IC50?=?8.12?μM), and 8r (IC50?=?7.06?μM) had better inhibitory activities against HCT-116 cells than the control 5-fluorouracil (IC50?=?29.50?μM). Additionally, compounds 8j, 8m, and 8r showed wonderful inhibitory activities against SGC-7901 cells with the IC50values of 11.46, 9.41, and 8.64?μM, respectively, which were superior to that of the control 5-fluorouracil.
View MoreCGeneTech (Suzhou, China) Co., Ltd.
Contact:+86-512-62956962
Address:Room 101,Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Contact:13120882795;+86-21-34621078;+86-021-31122318
Address:Suite 2,No.2715 Longwu Road
Wuhan Hanye Chemical New Material Co.,Ltd
Contact:+86-27-85308141
Address:LiuDian, Panlongcheng Economic Development Zone, HuangPi district, Wuhan, Hubei 430311 P.R.China
Contact:410-273-7300; 800-221-3953
Address:4609 Richlynn Dr., PO Box 369, Belcamp, MD, 21017-0369, USA
Shandong Xingshun New Material Co., Ltd.
website:http://www.sd-xingshun.com
Contact:+86-519-86461196/+86-519-86464994
Address:Middle of Luhua East Road, Dingtao District
Doi:10.1039/c5ra06337j
(2015)Doi:10.1002/anie.200803819
(2008)Doi:10.1016/j.ejmech.2017.11.098
(2018)Doi:10.1002/chem.202100527
(2021)Doi:10.1021/jo01103a024
(1958)Doi:10.1021/jo802378s
(2009)