THE PHOSPHOROTHIOITE METHOD 2. USE OF S-(t-BUTYL) β-CYANOETHYL PHOSPHOROTHIOITES OF DEOXYRIBONUCLEOSIDE FOR THE SYNTHESIS OF OLIGODEOXYRIBONUCLEOSIDES ON POLYMER SUPPORTS

Article abstract of DOI:10.1016/S0040-4039(00)95947-1

S-(t-butyl) β-cyanoethyl 3'-phosphorothioites of appropriately protected deoxyribonucleosides were prepared by the use of (t-butylthio)-β-cyanoethoxychlorophosphine as a new phosphitylating reagent.These compounds were found to be more stable than methyl