Synthesis and Physicochemical Properties of Thiadiazolopyrimidinesulfonamides and Thiadiazolotriazinesulfonamides as Candidates for Topically Effective Carbonic Anhydrase Inhibitors

DOI: 10.1021/jm00394a021

Source and publish data:

Journal of Medicinal Chemistry p. 2058 - 2062 (1987)

Update date:2022-08-05

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Authors:

Katritzky, Alan R.

Caster, Kenneth, C.

Maren, Thomas H.

Conroy, Curtis W.

Bar-Ilan, Amir

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Article abstract of DOI:10.1021/jm00394a021

A series of bicyclic 1,3,4-thiadiazolo<3,2-a>pyrimidine- and 1,3,4-thiadiazolo<3,2-a>triazine-7-sulfonamides were synthesized from 5-amino-1,3,4-thiadiazole-2-sulfonamide and evaluated for topical efficacy as ocular hypotensive agents.The compounds were t

Full text of DOI:10.1021/jm00394a021

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