Synthesis and Physicochemical Properties of Thiadiazolopyrimidinesulfonamides and Thiadiazolotriazinesulfonamides as Candidates for Topically Effective Carbonic Anhydrase Inhibitors

Article abstract of DOI:10.1021/jm00394a021

A series of bicyclic 1,3,4-thiadiazolo<3,2-a>pyrimidine- and 1,3,4-thiadiazolo<3,2-a>triazine-7-sulfonamides were synthesized from 5-amino-1,3,4-thiadiazole-2-sulfonamide and evaluated for topical efficacy as ocular hypotensive agents.The compounds were t