Facile Synthesis of 2-adenosine 5'-Diphosphate: A Key Intermediate for the Synthesis of Molecular Probes of Adenosine 5'-Diphosphate Function

Article abstract of DOI:10.1021/jm00394a015

Adenosine 5'-diphosphate (ADP) and, uniquely, its C-2 derivatized analogues are able to induce plateled activation.We here report the synthesis of 2-<(3-aminopropyl)thio>-ADP from ADP itself via 1,N⁶-etheno-ADP. 2-<(3-Aminopropyl)thio>-ADP induced platelet aggregation with a potency about one-seventh that of ADP itself and should prove a useful intermediate in the synthesis of other probes of platelet function.