A. J. Airaksinen et al.
reduced pressure and dissolved into phosphate buffer solution,
pH 7.4.
[5] P. E. J. Sanderson, Med. Res. Rev. 1999, 19, 179–197.
[6] N. Y. Chirgadze, D. J. Sall, V. J. Klimkowski, D. K. Clawson, S. L.
Briggs, R. Hermann, G. F. Smith, D. S. Gifford-Moore, J. P. Wery,
Protein Sci. 1997, 6, 1412–1417.
[7] K. J. Shaw, W. J. Guilford, J. L. Dallas, S. K. Koovakkaat, M. A.
McCarrick, A. Liang, D. R. Light, M. M. Morrissey. J. Med. Chem.
1998, 41, 3551–3556.
[8] E. W. Davie, J. D. Kulman, Semin. Thromb. Hemostasis 2006,
32(Suppl 1), 3–15.
[9] A. Schwienhorst. Cell. Mol. Life Sci. 2006, 63, 2773–2791.
[10] W. E. Dager, T. G. Vondracek, B. A. McIntosh, E. A. Nutescu, New
Drug Dev. 2004; 38: 1881–1897.
Conclusion
A fast and efficient method for synthesizing [11C]3 was
developed. [11C]3 was synthesized with good yield (27717%,
total overall DCY), giving 1.7571.0 GBq (47727 mCi) of radio-
chemically pure compound (497%) with a total synthesis time
of 45 min and relatively high specific radioactivity. The devel-
oped labeling procedure has a general utility to be also used in
11C-labeling of other benzamidoximes.
[11] B. Clement, K. Lopian, Drug Metab. Dispos. 2003; 31, 645–651.
¨
[12] D. Gustafsson, J.-E. Nystrom, S. Carlsson, U. Bredberg, U. Eriksson,
E. Gyzander, M. Elg, T. Antonsson, K.-J. Hoffmann, A.-L. Ungell, H.
˚ ˚
¨
Sorensen, S. Nagard, A. Abrahamsson, R. Bylund, Thromb. Res.
2001, 101, 171–181.
Acknowledgement
[13] U. G. Eriksson, U. Bredberg, K. J. Hoffmann, A. Thuresson, M.
´
Gustafsson, Drug Metab. Dispos. 2003, 31, 294–305.
[14] N. Malik, S. K. Luthra, P. Burke, P. M. Price, E. O. Aboagye, J. Latigo,
Y. Zhao, F. Brady, Appl. Radiat. Isot. 2004, 60, 825–834.
Babrielsson, H. Ericsson, M. Ahnoff, K. Gislen, G. Fager, D.
We thank Dr Raisa Krasikova (Institute of Human Brain, Russian
Academy of Science, St. Petersburg, Russia) and Arsalan Amir for
their technical assistance.
´
´
[15] F. Simeon, F. Sobrio, F. Gourand, L. Barre, J. Chem. Soc. Perkin.
Trans. 1 2001, 7, 690–694.
[16] D. R. Christman, R. D. Finn, K. I. Karlstrom, A. P. Wolf, Int. J. Appl.
Radiat. Isot. 1975, 26, 435–442.
[17] P. Truong, J. Andersson, A. Amir, C. Halldin, Q J. Nucl. Med. Mol.
Imaging 2006, 50(Suppl 1): 5.
[18] R. Iwata, T. Ido, T. Takahashi, H. Nakanishi, S. Iida, Appl. Radiat. Isot.
1987, 38, 97–102.
[19] M. Ponchant, F. Hinnen, S. Demphel, C. Crouzel, Appl. Radiat. Isot.
1997, 48, 755–762.
References
[1] B. Clement, Drug. Metab. Rev. 2002, 34, 565–579.
[2] H. Koshio, F. Hirayama, T. Ishihara, H. Kaizawa, T. Shigenaga, Y.
Taniuchi, K. Sato, Y. Moritani, Y. Iwatsuki, T. Uemura, S. Kaku, T.
Kawasaki, Y. Matsumoto, S. Sakamoto, S. Tsukamoto, Bioorg. Med.
Chem. 2004, 12, 5415–5426.
[3] S. Ku¨nzel, A. Schweinitz, S. Reismann, J. Stu¨rzebecher, T.
Steinmetzer, Bioorg. Med. Chem. 2002, 12, 645–648.
´
[4] T. Weller, L. Alig, M. Beresini, B. Blackburn, S. Bunting, P. Hadvary,
M. Mu¨ller-Hu¨rzeler, D. Knopp, B. Levet-Trait, M. T. Lipari, N. B. Modi,
˚
[20] Y. Andersson, B. Langstrom, J. Chem. Soc. Perkin Trans. I 1994, 11,
¨
1395–1400.
[21] J. Z. Ho, T. S. Gibson, J. E. Semple, Bioorg. Med. Chem. Lett. 2002,
12, 743–748.
[22] J. Andersson, P. Truong, A. Amir, C. Halldin. Q J. Label. Compd.
Radiopharm. 2007, 50(Suppl 1): S106.
¨
M. Mu¨ller, C. J. Refino, M. Schmitt, P. Schonholzer, S. Weiss, B.
Steiner, J. Med. Chem. 1996, 39, 3139–3147.
J. Label Compd. Radiopharm 2008, 51 1–5
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