A SIMPLE AND GENERAL ENTRY TO 5-SUBSTITUTED URUDINES BASED ON THE REGIOSELECTIVE LITHIATHION CONTROLLED BY A PROTECTING GROUP IN THE SUGAR MOIETY

DOI: 10.1016/S0040-4039(00)95656-9

Source and publish data:

Tetrahedron Letters p. 87 - 90 (1987)

Update date:2022-08-04

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Authors:

Hayakawa, Hiroyuki

Tanaka, Hiromichi

Obi, Kikoh

Itoh, Masayuki

Miyasaka, Tadashi

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Article abstract of DOI:10.1016/S0040-4039(00)95656-9

Lithiathion of 2',3',5'-tris-O-(tert-butyldimethylsilyl)uridine with sec-BuLi/TMEDA occurs at the C-5 position with a high regioselectivity and subsequent reactions of the resulting C-5 lithiated species with a variety of electrophiles provides a general entry to 5-substituted uridines.

Full text of DOI:10.1016/S0040-4039(00)95656-9

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