European Journal of Medicinal Chemistry p. 213 - 220 (1987)
Update date:2022-08-02
Topics:
Bilger, Christine
Demerseman, Pierre
Buisson, Jean-Pierre
Royer, Rene
Gayral, Philippe
Fourniat, Jacky
Modifications of biological activity following addition of a second nitrofuran cycle to nitroarenofuran homocycles. 2,7-dinitro-benzo<1,2-b:4,3-b'>difuran is prepared by direct nitration of 2-nitro-benzo<1,2-b:4,3-b'>difuran, whereas the corresponding derivatives nitrated in the α-position of each heterocycle of naphtho<2,1-b:7,6-b'>difuran, naphtho<2,1-b:6,5-b'>difuran, naphtho<1,2-b:6,5-b'>difuran and anthra<2,1-b:6,5-b'>difuran are obtained by condensation of bromonitromethane with appropriate bis-(ortho-hydroxyformyl) naphthalenes or anthracene.These dinitroarenodifurans are generally more efficient against bacteria and protozoa than 2-nitro-benzofuran itself and 2-nitro-naphthofurans.Keywords - arenodifurans/ nitroarenofurans/ anti-bacterial/ protozoicide
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