Sur quelques modifications d'activite biologique consecutives a l'accolement d'un second cycle nitrofuranne a l'homocycle de nitroarenofurannes

Article abstract of DOI:10.1016/0223-5234(87)90052-3

Modifications of biological activity following addition of a second nitrofuran cycle to nitroarenofuran homocycles. 2,7-dinitro-benzo<1,2-b:4,3-b'>difuran is prepared by direct nitration of 2-nitro-benzo<1,2-b:4,3-b'>difuran, whereas the corresponding derivatives nitrated in the α-position of each heterocycle of naphtho<2,1-b:7,6-b'>difuran, naphtho<2,1-b:6,5-b'>difuran, naphtho<1,2-b:6,5-b'>difuran and anthra<2,1-b:6,5-b'>difuran are obtained by condensation of bromonitromethane with appropriate bis-(ortho-hydroxyformyl) naphthalenes or anthracene.These dinitroarenodifurans are generally more efficient against bacteria and protozoa than 2-nitro-benzofuran itself and 2-nitro-naphthofurans.Keywords - arenodifurans/ nitroarenofurans/ anti-bacterial/ protozoicide