Cobalt Mediated Regioselective Alkylation of Methyl 3,5-Dioxohexanoate. Preparation of 5-Alkyl Derivatives of 4-Hydroxy-6-methyl-2-pyrone

Article abstract of DOI:10.1039/c39870000644

The cobalt(II) complex of the simple polyketide model methyl 3,5-dioxohexanoate is regioselectively alkylated to afford methyl 4-alkyl-3,5-dioxohexanoates, which cyclize on treatment with 1,8-diazabicyclo<5.4.0>undec-7-ene (DBU) to give 5-alkyl-4-hydroxy-