Chemistry of Heterocyclic Compounds p. 102 - 106 (1987)
Update date:2022-07-29
Topics:
Krauze, A. A.
Liepin'sh, E. E.
Pelcher, Yu. E.
Dubur,G. Ya.
The alkylation of piperidinium salts of substituted 1,4-dihydropyridine-2-thiols with chloroacetonitrile or iodoacetamide gave 2-cyanomethylthio- and 2-carbamoylmethylthio-substituted 6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-3-cyano-1,4-dihydropyridines, which undergo intramolecular cyclization in basic media to give 3-amino-6-methyl-4-aryl(pyridyl)-5-ethoxycarbonyl-2-cyano(carbamoyl)-4,7-dihydrothieno<2,3-b>pyridines.
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Doi:10.1002/chir.22770
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(2021)Doi:10.1248/cpb.35.4049
(1987)Doi:10.1039/P19900001513
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(1953)
