Synthesis of (±)-nitramine and (±)-isonitramine by utilizing stereoselective reduction of ethyl 1-(3-bromopropyl)-2-oxocyclohexanecarboxylate

Article abstract of DOI:10.3987/com-97-s40

Formal synthesis of (±)-nitramine (1) and (±)-isonitramine (2) was achieved. Thus, the reduction of ethyl 1-(3-bromopropyl)-2-oxocyclohexanccarboxylate (6) with NaBH₄ in MeOH gave the corresponding cyclohexanol (7) having cis geometry between h