OXYALLYLS IN SYNTHESIS: PREPARATION OF TRICYCLIC THROMBOXANE A2 ANALOGUES

DOI: 10.1016/S0040-4039(00)98749-5

Source and publish data:

Tetrahedron Letters p. 4411 - 4412 (1985)

Update date:2022-08-04

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Authors:

Bowers, Kevin G.

Mann, John

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Article abstract of DOI:10.1016/S0040-4039(00)98749-5

We describe the formation of 1-(dimethoxymethyl)-2-(2-phenylethenyl)-8-oxabicyclo<3.2.1>oct-6-en-3-ol (4) using oxyallyl methodology, and conversion of this into two 2,6-dioxatricyclo<3.3.1.0^3,7> nonanes (9) and (10) via iodoetherification and reduction.These compounds were then elaborated into the novel thromboxane analogues (11) and (12).

Full text of DOI:10.1016/S0040-4039(00)98749-5

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