Peptidomimetic synthesis: Utilization of N-acyliminium ion cyclization chemistry in the generation of 7,6- and 7,5-fused bicyclic lactams

Article abstract of DOI:10.1016/0040-4039(94)85062-3

A method for the stereoselective generation of 7,6- and 7,5-fused bicyclic lactams of type 1 has been developed. The key step involves intramolecular N-acyliminium ion cyclization of N-acyl enamine 2 to generate the core bicyclic framework. Lactams of typ