Synthesis p. 929 - 931 (1987)
Update date:2022-07-30
Topics:
Ahlbrecht, Hubertus
Ibe, Marcellinus
A new method for the synthesis of the title compounds by a one-pot reaction is described.It consists of the regioselective alkylation of a 1,3-dithio derivative of 3-cyanopropionaldehyde.The key intermediate is prepared by addition of lithioacetonitrile to 2-(N-methylanilino)acrylonitrile and subsequent lithiation.In a similar way, synthesis of symmetrical 3-cyanoalkane-1,5-diones is possible.
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Doi:10.1016/0022-328X(92)80125-H
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(2014)
