Synthesis p. 929 - 931 (1987)
Update date:2022-07-30
Topics:
Ahlbrecht, Hubertus
Ibe, Marcellinus
A new method for the synthesis of the title compounds by a one-pot reaction is described.It consists of the regioselective alkylation of a 1,3-dithio derivative of 3-cyanopropionaldehyde.The key intermediate is prepared by addition of lithioacetonitrile to 2-(N-methylanilino)acrylonitrile and subsequent lithiation.In a similar way, synthesis of symmetrical 3-cyanoalkane-1,5-diones is possible.
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Doi:10.1016/0022-328X(92)80125-H
(1992)Doi:10.1016/S0040-4039(98)00140-3
(1998)Doi:10.1021/jo00248a003
(1988)Doi:10.1021/ja00250a006
(1987)Doi:10.1055/s-0028-1083317
(2009)Doi:10.1007/s10847-013-0349-3
(2014)
