6020-87-7

Basic information

• Product Name: Creatine monohydrate
• Synonyms: N-GUANYL-N-METHYLGLYCINE;N-GUANYL-N-METHYLGLYCINE, MONOHYDRATE;N-METHYL-N-GUANYLGLYCINE MONOHYDRATE;N-AMIDINOSARCOSINE;N-AMIDINOSARCOSINE HYDRATE;N-AMIDINOSARCOSINE MONOHYDRATE;Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate;CREATINE HYDRATE
• CAS NO: 6020-87-7
• Molecular Formula: C₄H₉N₃O₂*H₂O
• Molecular Weight: 149.15
• EINECS: 200-306-6
• Product Categories: Food & Feed ADDITIVES;Nutritional Supplements;Food & Flavor Additives;API's;Biochemicals Found in Plants;Nutrition Research;Other Biochemical
• Mol File: 6020-87-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 292 °C (dec.)(lit.)
• Boiling Point: 271.6 °C at 760 mmHg
• Flash Point: 118.1 °C
• Appearance: White to yellow/Crystalline Powder
• Storage Temp.: Store at RT.
• Solubility: 17g/l
• Water Solubility: 13 g/L (20 ºC)
• Merck: 14,2568
• BRN: 907175
• CAS DataBase Reference: Creatine monohydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Creatine monohydrate(6020-87-7)
• EPA Substance Registry System: Creatine monohydrate(6020-87-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: MB7706000
• TSCA: Yes
• Hazardous Substances Data: 6020-87-7(Hazardous Substances Data)

Usage

Uses

1. Used in Sports and Fitness:
Creatine monohydrate is used as an ergogenic aid for athletes and weight trainers to enhance energy production, utilization, control, and efficiency. It is believed to increase power, strength, and muscle mass while decreasing performance time.
2. Used in Research and Development:
Creatine monohydrate is used as a supplement to study its uptake mechanism and metabolism of action in various research settings.
3. Used in the Treatment of Neuromuscular Diseases:
Creatine monohydrate is utilized in the treatment of certain neuromuscular diseases, where it may help improve muscle function and overall quality of life for patients.
4. Used in Pharmaceutical and Laboratory Applications:
Historically, creatine was primarily used as a laboratory reagent due to its relatively limited demand. However, with the rise in its popularity as a supplement, its use in pharmaceutical applications has also increased.
5. Used in the Food and Nutrition Industry:
Creatine monohydrate is found in various meals like meat, eggs, and fish, and is also available as a dietary supplement to support muscle growth and energy production.

Preparation

Creatine monohydrate can be synthesized in the laboratory (and commercially), starting from cyanamide and sarcosine (N-methylglycine).Creatine is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle by playing a key role in muscle energy metabolism. It is produced in the liver, pancreas, and kidneys and can also be derived from food and dietary supplements. Creatine provides the energy needed for muscle contraction and substantially improves performance in high-intensity exercise because it improves anaerobic capacity and protein synthesis. Therapeutically, it has been used to treat some types of muscular dystrophy, ocular atrophy, and some types of sclerosis. Creatine (a dietary supplement) is demanded by many athletes and is neither regulated by the Food and Drug Administration (FDA) nor prohibited by the International Olympic Committee (IOC).

benefits

Creatine has many benefits for health and performance. The most common is creatine monohydrate, a dietary supplement that improve strength, increase lean muscle mass, and help the muscles recover more quickly during exercise. It can also inhibit the generation of muscle fatigue factors, reduce fatigue and tension, restore physical fitness, accelerate protein synthesis in the human body, make muscles stronger, enhance muscle elasticity, reduce cholesterol, blood lipids, and blood sugar levels, improve middle-aged and elderly Muscular dystrophy, and delay aging.

InChI:InChI=1/C4H9N3O2/c1-7(4(5)6)2-3(8)9/h2H2,1H3,(H4,5,6,8,9)

Synthetic route

sarcosine (107-97-1) + 2-{[amino(imino)methyl]sulfanyl}acetic acid (7404-50-4) → creatine monohydrate powder (6020-87-7)

Conditions	Yield
at 60℃; for 3h;	80%

CYANAMID (420-04-2) + sodium sarcosinate (4316-73-8) → creatine monohydrate powder (6020-87-7)

Conditions	Yield
In water
With water at 20 - 80℃; for 1h; Temperature; Large scale;

phosphonic Acid (13598-36-2) + water (7732-18-5) + creatine monohydrate powder (6020-87-7) + zinc(II) oxide → Zn(2+)*2C4N3OH7*HPO3(2-)*H2O=(C4N3OH7)2Zn(H2O)HPO3

Conditions	Yield
In water creatine, ZnO, H3PO3 (6:1:2), and water were shaken and heated at 70°C for 24 h (pH 6); ppt. was filtered;	76%

phosphonic Acid (13598-36-2) + water (7732-18-5) + creatine monohydrate powder (6020-87-7) + zinc(II) oxide → (C4N3OH7Zn(H2O)HPO3)2

Conditions	Yield
In water creatine, ZnO, H3PO3 (4:1:4), and water were shaken and heated at 70°C for 24 h (pH 4); ppt. was filtered;	61%

phosphonic Acid (13598-36-2) + creatine monohydrate powder (6020-87-7) + zinc(II) oxide → Zn(2+)*CH3N2C3H2ONH2*HPO3(2-)=C4N3OH7ZnHPO3 (503588-77-0)

Conditions	Yield
In water creatine hydrate, ZnO, H3PO3 (5:1:3), and water were shaken and heated at 70°C for 24 h (pH 5); ppt. was filtered;	51%

disodium creatine phosphate tetrahydrate + creatine monohydrate powder (6020-87-7) → creatinine (60-27-5)

disodium creatine phosphate tetrahydrate + creatine monohydrate powder (6020-87-7) → creatinine (60-27-5) + Creatinine (57-00-1)

Upstream product

• 107-97-1 sarcosine 
• 7404-50-4 2-{[amino(imino)methyl]sulfanyl}acetic acid 
• 420-04-2 CYANAMID 
• 4316-73-8 sodium sarcosinate 

Downstream Products

• 60-27-5 creatinine 
• 57-00-1 Creatinine 

Relevant articles and documents

Clean production method of mercaptan compound

The invention provides a clean production method of a mercaptan compound. There are two technological steps: Step 1, thiourea and halogenated hydrocarbon or active conjugated alkene react at 20-150 DEG C for 1-18 h, and after neutralization, S-alkylisothiourea is obtained; and Step 2, S-alkylisothiourea and aliphatic primary amine or secondary amine react at 20-180 DEG C for 1-24 h to obtain the mercaptan compound, and simultaneously, a substituted guanidino compound is coproduced. The mercaptan production technology has mild condition and high yield, hardly has discharge of ''three wastes (waste gas, waste water and industrial residue) '', and is a clean production method.

Process for the preparation of creatine water (by machine translation)

The invention discloses a preparation method of creatine monohydrate, and provides the preparation method of the creatine monohydrate. The method comprises the following steps: step 1, carrying out a nucleophilic substitution reaction on a glycolonitrile aqueous solution and a methylamine aqueous solution for 1 to 6 hours at a temperature of 10 DEG C to 40 DEG C so as to generate methylamino acetonitrile; step 2, carrying out a hydrolysis reaction on the methylamino acetonitrile reaction liquid obtained in the step 1 for 2 to 6 hours at the temperature of 60 DEG C to 80 DEG C and in the presence of sodium hydroxide so as to obtain a sodium sarcosinate aqueous solution; step 3, regulating pH to 9 to 12 and carrying out a condensation reaction on the sodium sarcosinate aqueous solution and the cyanamide for 1 to 6 hours at the temperature of 50 DEG C to 90 DEG C so as to obtain the creatine monohydrate. The method is moderate in reaction condition, less in byproduct, high in yield and suitable for industrial production. The structure of the creatine monohydrate is as shown in the specification.

PROCESS FOR STRAIGHTENING KERATIN FIBRES WITH A HEATING MEANS AND DENATURING AGENTS

The invention relates to a process for straightening keratin fibres, comprising: (i) a step in which a straightening composition containing at least two denaturing agents is applied to the keratin fibres, (ii) a step in which the temperature of the keratin fibres is raised, using a heating means, to a temperature of between 110 and 250° C.

Preparation of substituted guanidine derivative

Substituted guanidine derivatives of the formula I, STR1 are prepared by reacting haloformamidinium salts of the formula II, STR2 where Hal can be Cl, F, Br and I, with primary or secondary amines of the formula III STR3 where the substituents R1 and R2 have the meanings explained in the description.

Process for the preparation of a creatine or creatine monohydrate

Disclosed is a process for the preparation of creatine or creatine monohydrate, wherein cyanamide is reacted with sodium or potassium sarcosinate in water or in a mixture of water and en organic solvent at a temperature of from 20 to 150° C. and a pH value of from 7.0 to 14.0. By means of the process according to the present invention, creatine or creatine monohydrate can be prepared in good yields of from 60 to 90% by weight and with very high purity.