Synthesis of 5-fluoroalkylated pyrimidine nucleosides via Negishi cross-coupling

DOI: 10.1021/jo800444y

Source and publish data:

Journal of Organic Chemistry p. 4874 - 4881 (2008)

Update date:2022-08-05

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Authors:

Chacko, Ann-Marie

Qu, Wenchao

Kung, Hank F.

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Article abstract of DOI:10.1021/jo800444y

(Chemical Equation Presented) 5-Fluoroalkylated pyrimidine nucleosides (1) have potential as therapeutic agents and molecular imaging agents targeting HSV1-tk suicide gene therapy. Thus, straightforward preparation of 5-fluoroalkylated nucleoside derivati

Full text of DOI:10.1021/jo800444y

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