Organic Letters p. 5068 - 5071 (2010)
Update date:2022-07-29
Topics:
Ohtani, Takashi
Tsukamoto, Shinya
Kanda, Hiroshi
Misawa, Kensuke
Urakawa, Yoshifumi
Fujimaki, Takahiro
Imoto, Masaya
Takahashi, Yoshikazu
Takahashi, Daisuke
Toshima, Kazunobu
The first total synthesis of incednam (1), the aglycon of antibiotic incednine (2), is described. Incednine has been reported to exhibit significant inhibitory activity against the antiapoptotic oncoproteins Bcl-2 and Bcl-xL. The synthesis of 1 commenced
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