Synthesis p. 1108 - 1110 (1987)
Update date:2022-08-03
Topics:
Gajda, Tadeusz
1-Primary, 3-secondary 1,3-alkanediols can be selectively aminated at C-1 via OH/NH2 exchange by reaction with diethyl N-Boc-phosphoramidate in ether using triphenylphosphine/diethyl diazenedicaboxylate as condensing agent, and treatment of the resultant diethyl N-Boc-N-(3-hydroxyalkyl)phosphoramidates with 4-nitrobenzoyl chloride/pyridine, followed by dephosphorylation with hydrogen chloride in ethyl acetate.The reaction sequence affords the hydrochlorides of 3-aminoalkyl 4-nitrobenzoates in good yields.
View MoreSichuan Mianzhu Ronghong Chemical Co.,LTd
Contact:8613981840544
Address:XINSHI INDUSTRY PARK,MIANZHU,SICHUAN,CHINA
Contact:+8613400661290
Address:No 908,Kangwan Rd, Liuyang Economic
Sichuan Sangao Biochemical Co., Ltd
Contact:+86-28-84874233
Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Anhui Eapearl Chemical Co., Ltd.
Contact:86-562-5858458
Address:358 South Huaihe Road
Doi:10.1016/j.jfluchem.2008.04.012
(2008)Doi:10.1016/S0040-4039(00)86723-4
(1988)Doi:10.3109/14756366.2015.1029470
(2016)Doi:10.1016/j.bmcl.2009.02.110
(2009)Doi:10.1007/BF00768251
(1988)Doi:10.1016/j.jorganchem.2008.12.011
(2009)
