SYNTHETIC STUDIES ON TETRODOTOXIN (1) STEREOCONTROLLED SYNTHESIS OF THE CYCLOHEXANE MOIETY

DOI: 10.1016/S0040-4039(00)96895-3

Source and publish data:

Tetrahedron Letters p. 6485 - 6488 (1987)

Update date:2022-08-04

Topics:

Authors:

Isobe, Minoru

Nishikawa, Toshio

Pikul, Stanislaw

Goto, Toshio

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Article abstract of DOI:10.1016/S0040-4039(00)96895-3

Tetrodotoxin is a potent neurotoxin, for which we planned a chemical synthesis in the optically active form.The key steps are i) Diels-Alder cycloaddition to form the optically active system with the cyclohexane moiety, ii) introduction of one-carbon frag

Full text of DOI:10.1016/S0040-4039(00)96895-3

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