Tetrahedron Letters p. 6485 - 6488 (1987)
Update date:2022-08-04
Topics:
Isobe, Minoru
Nishikawa, Toshio
Pikul, Stanislaw
Goto, Toshio
Tetrodotoxin is a potent neurotoxin, for which we planned a chemical synthesis in the optically active form.The key steps are i) Diels-Alder cycloaddition to form the optically active system with the cyclohexane moiety, ii) introduction of one-carbon frag
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