Erratum: Aromatic amines as nucleophiles in the Bargellini reaction (Tetrahedron Letters (2009) 50 (2497-2500))

Full text of DOI:10.1016/j.tetlet.2010.10.001

Tetrahedron Letters 51 (2010) 6677–6678
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Tetrahedron Letters
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Corrigendum
Corrigendum to ‘‘Aromatic amines as nucleophiles in the Bargellini
reaction” [Tetrahedron Letters 50 (2009) 2497–2500]
⇑
Ken J. Butcher , Jenny Hurst
Pfizer Global Research and Development, Sandwich Laboratories, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK
The authors regret that when this paper was published the following artwork structures were incorrect.
Table 1, Entry 1 and Scheme 4 should read as follows:
1
Br
OH
Br
O
CO2H
44
CH2
Scheme 4
Representative traditional route
O
NH CONH
NH CN
2
a, b
c
N
N
N
Ph
Ph
Ph
O
H
N
CO Me
2
N
CO H
2
d,e
f-h
N
N
P h
Ph
a.Aniline, KCN, AcOH,2 h b. EtOHrecryst.c. cH2SO4 d.KOH, ethylene glycol,150 °C 4d e.H2O,
AcOH f. NaH, DMFg. MeI h. Propionic anhydride, reflux, 3 d.
DOI of original article: 10.1016/j.tetlet.2009.03.044
Corresponding author. Tel.: +44 1304 644692.
E-mail address: ken.butcher@pfizer.com (K.J. Butcher).
⇑
0040-4039/$ - see front matter Ó 2009 Elsevier Ltd. All rights reserved.
doi:10.1016/j.tetlet.2010.10.001

6678
K. J. Butcher, J. Hurst / Tetrahedron Letters 51 (2010) 6677–6678
Improved, aniline Bargellini route
O
H
N
O
CO H
N
CO Me
2
2
a
b, c
N
N
N
Boc
Boc
Boc
a. Aniline,NaOH,CHCl3,THF, 70% b.Propionicanhydride, Et3N, EtOAc,1h c.MeOH,2 h,70% over
2 steps.